منابع مشابه
Mole Tar
Downloa ent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in igenesis and cancer progression have generated significant interest in therapeutic agents that ctly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function 4E in translation initiation and cancer, present evidence supporting its role in cancer initiati...
متن کاملMole Evid
Downlo ptive response (AR) is a term describing resistance to ionizing radiation–induced killing or formation of nt chromosomes that is mediated by pre-exposure to low ionizing radiation doses. The mechanism of ains elusive. Because cell killing and chromosome aberration formation derive from erroneous procesf DNA double-strand breaks (DSB), AR may reflect a modulation of DSB processing by nonh...
متن کاملMole Tar
Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...
متن کاملMole Sele
Downlo inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent ting mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were sento a novel series of Raf inhibitors (e.g., B-Raf A375, IC50 on cells = 2 nmol/L; ED50 on tumor rafts = 1.3 mg/kg). However, in cells and tumors with wild-type B-Raf, exposure to Raf inhib...
متن کاملNaked mole-rat
It’s a mammal Jim, but not as we know it... Mammals are typically characterised as furry and warmblooded. The naked mole-rat is neither of these. Being underground and surrounded by hundreds of brothers and sisters, there is little fluctuation in surrounding temperature and they have all but lost the ability to regulate their body temperature physiologically. Living in the dark, they can no lon...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 1973
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.1491